Normality of oligonucleotide microarray data and implications for parametric statistical analyses
نویسندگان
چکیده
منابع مشابه
Normality of oligonucleotide microarray data and implications for parametric statistical analyses
MOTIVATION Experimental limitations have resulted in the popularity of parametric statistical tests as a method for identifying differentially regulated genes in microarray data sets. However, these tests assume that the data follow a normal distribution. To date, the assumption that replicate expression values for any gene are normally distributed, has not been critically addressed for Affymet...
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15 صفحه اولTransformation and normalization of oligonucleotide microarray data
MOTIVATION Most methods of analyzing microarray data or doing power calculations have an underlying assumption of constant variance across all levels of gene expression. The most common transformation, the logarithm, results in data that have constant variance at high levels but not at low levels. Rocke and Durbin showed that data from spotted arrays fit a two-component model and Durbin, Hardin...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2003
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btg311